Вивчення спектру фармакологічної активності нової мазі з антисептиком для лікування ран в першій фазі раньового процесу

Abstract

A study of pharmacological spectrum of activity of a new ointment with ethonium on antimicrobial (the diffusion method in agar), anti-inflammatory (against carragenininduced paw edema in rats) and wound healing effect (model of a linear cut wounds in rats) was carried out. By the diffusion method in agar was found that the ointment with ethonium inhibits growth of Escherichia coli, Pseudomonas aeruginosae, Bacillus subtilis, Proteus vulgaris, Candida albicans. On the carragenin-induced paw edema in rats was proved that an ointment with ethonium has a pronounced anti-inflammatory effect, which in 2.3 times exceeded the effect of reference medicine. On the model of a linear cut wounds in rats was found that an ointment with ethonium promotes wound healing and scar formation, its therapeutic effect exceedes an effect of Levosin ointment. These results motivate further pharmacological study of a new ointment with ethonium with clinical purpose in the treatment of wounds.