Use this url to cite publication: https://hdl.handle.net/20.500.12512/238044
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The Translational Impact of Plant-Derived Xeno-miRNA miR-168 in Gastrointestinal Cancers and Preneoplastic Conditions
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Link, Jastin | Otto-von-Guericke University |
Thon, Cosima | Otto-von-Guericke University |
Malfertheiner, Peter | Otto-von-Guericke University |
Link, Alexander | Otto-von-Guericke University |
Title
The Translational Impact of Plant-Derived Xeno-miRNA miR-168 in Gastrointestinal Cancers and Preneoplastic Conditions
Publisher (trusted)
Date Issued
2023-08-18
Is part of
Diagnostics
Version
Originalus / Original
Description
Art. no. 2701.
This article belongs to the Special Issue Diagnosis and Management of Gastrointestinal Inflammation
Volume
13
Issue
16
Start Page
1
End Page
15
Field of Science
OECD Classification
Abstract
Diet is one of the most important factors contributing to the multistep process of carcinogenesis. The clinical relevance of exogenous food-derived xeno-microRNAs (miRNAs) in human diseases is poorly understood. In this study, we aimed to evaluate the potential clinical relevance of the xeno-miRNA miR-168 in the gastric mucosa along the preneoplastic conditions and gastric carcinogenesis.
For a systematic analysis, we included stomach tissues from patients with different pathologies, including normal mucosa (N), chronic non-atrophic (CNAG) and atrophic gastritis (CAG) and intestinal metaplasia (IM) (n = 72), matched non-tumorous (NT) and tumorous (T) gastric cancer (GC) tissues (n = 81), matched colorectal cancer (CRC) tissues (n = 40), and colon mucosa and faeces from controls and IBD patients.
miR-168 was reproducibly detectable in all samples studied, with the highest levels in the proximal upper GI and in non-tumorous compared to tumorous tissues in both GC and CRC. There was no difference related to positivity or inflammation grade, while higher miR-168 levels were observed in patients with moderate or severe AG/IM or OLGIM3/4. Survival analysis showed only a small, non-significant trend towards worse overall survival for patients with the highest to lowest miR-168 levels, while no differences were related to Lauren's classification.
Food-derived xeno miRNAs are reproducibly detectable in the gastric and colonic mucosa. Although the clinically relevant function remains to be elucidated, higher levels of miR-168 in patients with moderate and severe IM merit further investigation.
Is Referenced by
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
2075-4418
WOS
001056170100001
Other Identifier(s)
PMCID: PMC10453613
Coverage Spatial
Šveicarija / Switzerland (CH)
Language
Anglų / English (en)
Bibliographic Details
43
Funding(s)
Funding(s) | Grant No | Project ID |
---|---|---|
MOL-CRC-SCREEN | 01.2.2-LMT-K-718-03-0086 | |
European Regional Development Fund | ||
Lietuvos mokslo taryba (LMTLT) | ||
BMBF | BMBF-0315905D |
Date Reporting
2023
Creative Commons License
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Diagnostics | 3.6 | 6.8 | 6.8 | 6.8 | 1 | 0.529 | 2022 | Q2 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Diagnostics | 3.6 | 6.8 | 6.8 | 6.8 | 1 | 0.529 | 2022 | Q2 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Diagnostics | 3.6 | 0.982 | 0.67 | 2022 | Q3 |