Apparent diffusion coefficient (ADC) in pancreatic adenocarcinoma

Abstract

Purpose The aim of our study was to identify mean ADC value in different grade of pancreatic adenocarcinoma and nontumorous pancreatic tissue. Material and methods 23 patients with surgically confirmed pancreatic adenocarcinoma patients were analysed in this study; restriction of diffusion was analysed and we calculated mean ADC value of tumorous tissue and compared results with histopathological data in different tumor grade. All calculations were performed using SPSS for Windows 22.0 software. Results Three b values (b value = 50, 400 and 800 s/mm2) were measured to calculate ADC value of the tumor and nontumorous parenchymal tissue. The mean ADC value of pancreatic tumor was significantly lower (1.172+-0.12 x 10-3mm2/s) than in „healthy“ tissue (1.333+-0.055 x 10-3mm2/s), p<0.05 and it was even more lower in poorly differenciated adenocarcinomas (1.07+-0.067 x 10-3mm2/s), but the difference was not statistically significant. Conclusion Mean ADC value in pancreatic adenocarcinoma was significantly lower than in nontumorous tissue. Mean ADC value in poorly differenciated adenocarcinomas was even more lower, but the difference was not statistically significant. Further investigations with larger patient’s groups are needed.