The Analysis of structure of electrospun nonwoven material from Eudragit L100 nano-microfibers

Abstract

Synthetic biodegradable polymers, attracted special attention in electrospinning due to the elimination of a second surgery to remove the implant carrier. Because the rate of degradation can be controlled to some extent by altering parameters such as polymer blend composition or pH changes. Electrostatic spinning or electrospining is a process by which ultrafine bibers with diameters in the sub micrometer down to nanometer range can be produced. These fibers interesting several characteristics, for examples, large surface area to mass or volume ratio, small pore size between depositing fibers of the electrospun mat, and flexibility for surface functionalization. Eudragit L-100 (EDGT) is a common enteric coating composed of anionic blocks of methacrylic acid and methyl methacrylate with ratio of acid to ester of 1:1. One of the EDGT properties is that the biodegradation is to pH changes. the aim of this study is to produce nonwoven material from anionic copolymer EDGT and determine the influence of polymer concentration on diameter of electrospun nano - microfibers. [...].