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Cognitive functioning of males with coronary artery disease: the role of obstructive sleep apnoea and inflammatory biomarkers
Fineberg, Naomi Anne | National Obsessive Compulsive Disorders Specialist Service, Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, United Kingdom |
| Date Issued |
|---|
2021-11-26 |
no. 7
Poster presentations
ISBN 978-609-07-0679-4 (digital PDF)
Bibliogr.: p. 27
Introduction: Males are especially vulnerable to obstructive sleep apnoea (OSA) presenting as an independent risk factor for adverse cardiac outcomes and impaired cognitive functioning [1]. Increased concentrations of inflammatory biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP), are common in individuals with coronary artery disease (CAD) and have also been associated with impaired cognitive functioning [2] and unfavourable CAD prognosis [3]. Although proposed theoretically [4], the effect of an interaction between OSA and these biomarkers on cognitive function has not so far been thoroughly investigated in the clinical setting. The aim of our exploratory study was to determine whether OSA interacting with NT-proBNP and hsCRP has an effect on specific aspects of cognitive functioning in males with CAD. Method: In sum, 328 males (mean age 57±10 years), undergoing cardiac rehabilitation, were evaluated for socio-demographic and clinical risk factors as well as NT-proBNP and hsCRP serum levels. Cognitive functioning testing included the Digit Symbol Substitution Test (DSST), and Trail Making Test Part A (TMTA). Participants underwent full-night polysomnography and were classified in mild/non-OSA (n=253) and OSA (n=75) according to an apnoea-hypopnea index (AHI) ≥15 event/h (3% or arousal). Several analyses of variance (ANOVA) were performed on cognitive functioning for (OSA vs mild/non-OSA) group interaction with NT-proBNP (<157.0 vs ≥157.0 ng/L) and with hsCRP (<0.39 vs ≥0.39 mg/dL). Results: Significant group (OSA, mild/non-OSA) × NT-proBNP (<157.0 vs. ≥157.0 ng/L) interactions were found only for the DSST raw score (F2,324=5.06, P=.002). There was a tendency for group (OSA, mild/non-OSA) × NT-proBNP (<157.0 vs ≥157.0 ng/L) interactions for the TMTA (F3,324=3.67, P=.013). Tendency was also observed for group (OSA, mild/non-OSA[...].