A Construct for Articular Cartilage Regeneration and a Method of Preparation (EP 4119169 A1)
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Dabašinskaitė, Lauryna | Naujo proceso autorius / Inventor | Kauno technologijos universitetas | |
Martuzevičius, Dainius | Naujo proceso autorius / Inventor | Kauno technologijos universitetas | |
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Naujo proceso autorius / Inventor | |||
Baniukaitienė, Odeta | Naujo proceso autorius / Inventor | Kauno technologijos universitetas | |
Krugly, Edvinas | Naujo proceso autorius / Inventor | Kauno technologijos universitetas | |
Čiužas, Darius | Naujo proceso autorius / Inventor | Kauno technologijos universitetas | |
Lietuvos sveikatos mokslų universitetas | Patento pareiškėjas / Patent applicant | ||
Kauno technologijos universitetas | Patento pareiškėjas / Patent applicant |
| Date | Start Page | End Page |
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2023-01-18 | 1 | 14 |
Priority: EP20210186137 20210716 | Application: EP20210186137 20210716 | Int. Cl.: A61L27/46; A61L27/48; A61L27/50; A61L27/54; A61L27/56; A61L27/58; | Published as: EP 4119169 (A1), EP4119169 (B1), EP4119169 (C0)
The base of the regeneration construct scaffold is a biodegradable polymer. The biodegradable polymer is blended with natural additives, such as cellulose and hydroxyapatite which increase tissue affinity. The regeneration construct is composed of two layers, where layer I comprises blend of biodegradable polymer and cellulose and is prepared for cartilage tissue formation; and layer II comprises blend of biodegradable polymer, cellulose, and hydroxyapatite and is prepared for subchondral bone tissue formation. A method of preparation of construct comprises preparation of polymer solutions for layers I and II, applying of solution cryo-electrospinning, conversion of cellulose acetate to cellulose, surface modification of the regeneration construct layer I scaffold by treating with ozone, embedding of biologically active molecules in the regeneration construct scaffold layer I; sterilization of the regeneration construct layer I and II scaffold and combining of the regeneration construct layer I and II scaffolds in order to form final regeneration construct.