Use this url to cite publication: https://hdl.handle.net/20.500.12512/117079
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Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Vilniaus universitetas | ||
D’Avanzo, Nicola | University of Chieti – Pescara “G. d’Annunzio” | University Magna Græcia of Catanzaro Campus Universitario-Germaneto |
University of Chieti – Pescara “G. d’Annunzio” | ||
Fresta, Massimo | University of Catanzaro “Magna Graecia” |
Title
Nanocarriers overcoming biological barriers induced by multidrug resistance of chemotherapeutics in 2D and 3D cancer models
Publisher (trusted)
Churchill Livingstone |
Is Referenced by
Date Issued
Date Issued | Volume | Start Page | End Page |
---|---|---|---|
2023-03-12 | 68 | 1 | 18 |
Is part of
Drug Resistance Updates
Version
Originalus / Original
Description
art. no. 100956.
Mokslo kryptis nurodė autorė Vilma Petrikaitė (Biologija (30%), cheminė inžinerija (50%), medicina (20%))
OECD Classification
Abstract
Multidrug resistance (MDR) is currently a big challenge in cancer therapy and limits its success in several patients. Tumors use the MDR mechanisms to colonize the host and reduce the efficacy of chemotherapeutics that are injected as single agents or combinations. MDR mechanisms are responsible for inactivation of drugs and formbiological barriers in cancer like the drug efflux pumps, aberrant extracellular matrix, hypoxic areas, altered cell death mechanisms, etc. Nanocarriers have some potential to overcome these barriers and improve the efficacy of chemotherapeutics. In fact, they are versatile and can deliver natural and synthetic biomolecules, as well as RNAi/DNAi, thus providing a controlled release of drugs and a synergistic effect in tumor tissues. Biocompatible and safe multifunctional biopolymers, with or without specific targeting molecules, modify the surface and interface properties of nanocarriers. These modifications affect the interaction of nanocarriers with cellular models as well as the selection of suitable models for in vitro experiments. MDR cancer cells, and particularly their 2D and 3D models, in combination with anatomical and physiological structures of tumor tissues, can boost the design and preparation of nanomedicines for anticancer therapy. 2D and 3D cancer cell cultures are suitable models to study the interaction, internalization, and efficacy of nanocarriers, the mechanisms of MDR in cancer cells and tissues, and they are used to tailor a personalized medicine and improve the efficacy of anticancer treatment in patients. The description of molecular mechanisms and physio-pathological pathways of these models further allow the design of nanomedicine that can efficiently overcome biological barriers involved in MDR and test the activity of nanocarriers in 2D and 3D models of MDR cancer cells.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
1368-7646
1532-2084
WOS
000959296500001
Other Identifier(s)
(LSMU ALMA)991694286907106
Coverage Spatial
Jungtinė Karalystė / United Kingdom of Great Britain and Northern Ireland (GB)
Language
Anglų / English (en)
Bibliographic Details
201
Funding(s)
Funding(s) | Grant No | Project ID |
---|---|---|
European Cooperation in Science and Technology (COST) | 17104 | |
LT-CZ Bilateral Project | LAS-21-04 |
Date Reporting
2023
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
DRUG RESISTANCE UPDATES | 24.3 | 4.5 | 4.5 | 4.5 | 1 | 5.4 | 2022 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
DRUG RESISTANCE UPDATES | 24.3 | 4.5 | 4.5 | 4.5 | 1 | 5.4 | 2022 | Q1 |
4.6 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Drug Resistance Updates | 34.8 | 3.535 | 4.391 | 2022 | Q1 |