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Type of publication: conference paper
Type of publication (PDB): Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004);Biologija / Biology (N010)
Author(s): Mongirdienė, Aušra;Abramavičiūtė, Agnė;Karčiauskaitė, Dovilė;Mazgelytė, Eglė;Liekis, Arūnas;Sadauskienė, Ilona
Title: The Difference of oxidative stress readings in patients diagnosed with chronic heart failure
Is part of: Medicina : Abstracts of the International Scientific Conference on Medicine organized within the frame of the 81st International Scientific Conference of the University of Latvia : 10 February 2023, Riga / University of Latvia ; Editor-in-Chief Edgaras Stankevičius. Kaunas ; Basel : LSMU ; MDPI, 2023, vol. 59, suppl. 1
Extent: p. 31-31
Date: 2023
Note: Oral presentations. Cardiovascular and regenerative medicine
Abstract: Background. With respect to structural and functional cardiac disorders, heart failure (HF) is divided into HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). HfrEF is known to be the outcome of myocardial ischemia and infarction. Notably, HFpEF is associated with dysregulated metabolism and chronic hypertension, contributing to oxidative stress and myocardial dysfunction. Oxidative stress (an imbalance between the increased formation of reactive oxygen species (ROS) and the elimination or neutralization of ROS by an antioxidant system) plays an important role in the development of chronic HF and correlates with left ventricle dysfunction and hypertrophy in the failing heart. So, oxidative and antioxidative stress biomarker levels should be higher in HFpEF. Aim. The aim was to compare oxidative stress (nitrotyrosine, dityrosine, protein carbonyl, malondialdehyde, oxidized HDL) and antioxidative biomarker (total plasma antioxidant capacity, catalase (CAT)) levels in the blood between HFrEF and HFpEF patient groups. Methods. A total of 60 CHF patients were enrolled in the study and divided into two groups: HFpEF of 114.29 μg/L), different protein carbonyl (≤259.95 vs. >259.95 U/mL) and oxidized HDL levels (≤3.06 vs. >3.06 pg/L). There was no correlation between the readings too. Conclusion. Oxidative stress and antioxidative biomarker levels in the blood between HFrEF andHFpEF patient groups do not differ
Affiliation(s): Biochemijos katedra
Lietuvos sveikatos mokslų universitetas
Molekulinės neurobiologijos laboratorija
Vilniaus universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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