Bone Tissue Regeneration in Cellulose

Abstract

Nowadays much attention is focused on polymer-ceramic three-dimensional scaffolds for bone tissue regeneration in defect size. For a successful performance the ideal scaffold be a 3D interconnected porous structure able to promote cell adhesion, proliferation and vascularisation, while enabling a controlled supply of bioactive substances that might influence the behaviour of incorporated or ingrown cells. In this work cellulose-based porous composities with hydroxyapatite for the bone scaffold were investigated. The composites were fabricated by saponification of diacetylcellulose adding hydroxyapatite. After the reaction the obtained gel of regenerated cellulose was homogeneously immobilized with hydroxyapatite. In order to create suitable matrix the composites were freeze-dried. It was found out that the conditions of lyophilisation highly influenced the morphology of the matrix. The porosity of the scaffolds was up to 75% with pores of different sizes up to 770 μm. [...].