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dc.contributor.authorPetrauskaitė, Odeta-
dc.contributor.authorLiesienė, Jolanta-
dc.contributor.authorSantos, Catarina-
dc.contributor.authorGomes, Pedro de Sousa-
dc.contributor.authorGarcia, Mónica Pereira-
dc.contributor.authorFernandes, Maria Helena Raposo-
dc.contributor.authorAlmeida, Maria Margarida-
dc.contributor.authorCosta, Maria Elisabete Jorge Vieira-
dc.contributor.authorJuodžbalys, Gintaras-
dc.contributor.authorDaugėla, Povilas-
dc.description.abstractBone engineering via synthetic biomaterials implies the interplay of various agents including a synthetic scaffold, bone progenitor cells and growth factors. To perform successfully the ideal scaffold should be a 3D interconnected porous structure promoting cell adhesion, proliferation and vascularisation and allowing bioactive substances to be supplied to incorporated or ingrown cells. The present work explores the preparation and characterization of cellulose/hydroxyapatite composite structures for bone tissue regeneration in maxillofacial region and their osteoblastic cytocompatibility. Cellulose/hydroxyapatite porous scaffolds were produced by freeze drying suspensions of cellulose and chemically synthesized hydroxyapatite nanoparticles. Experimental parameters including cellulose concentration, pre-lyophilisation condition, and hydroxyapatite nanoparticle morphology were used to manipulate scaffold porosity, micron- and nano-scale topography. The biological characterization of cellulose/hydroxyapatite composites was conducted with MG-63 human osteoblastic-cells. The obtained freezedried bodies are highly porous, with pore size ranging from micron to nanometric scale. Furthermore, assayed composites revealed improved biological profile, by enhancing the adhesion, poliferation and functional activity of seeded osteoblastic-like cells. Attained results substantiate the suitable application of cellulose//hydroxyapatite scaffolds in bone tissue engineering applicationsen
dc.description.sponsorshipKauno technologijos universitetas-
dc.description.sponsorshipLietuvos sveikatos mokslų universitetas-
dc.description.sponsorshipVeido ir žandikaulių chirurgijos klinika-
dc.format.extentp. 34, no. 04.P15-
dc.relation.ispartofJournal of Tissue Engineering and Regenerative Medicine : 3rd TERMIS World Congress : September 5-8, 2012, Vienna, Austria : abstract book / Editor-in-Chief: Rui L. Reis. Chichester, West Sussex, UK : John Wiley & Sons, 2012, vol. 6, suppl. 1, September-
dc.relation.ispartofseries(04. Hypertrophic Cartilage and Bone Tissue Engineering)-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.subjectBone regenerationen
dc.subjectTissue engineeringen
dc.subjectBiocompatible materialsen
dc.subjectCarboxymethylcellulose sodiumen
dc.subjectMaterials testingen
dc.subject.classificationTezės Clarivate Analytics Web of Science ar/ir Scopus / Theses in Clarivate Analytics Web of Science and/or Scopus DB (T1a)-
dc.subject.otherBiologija / Biology (N010)-
dc.titleNano-hydroxyapatite/cellulose composite scaffold for bone tissue engineeringen
dc.typeconference paper-
item.fulltextNo Fulltext-
item.grantfulltextnone- sveikatos mokslų universitetas- sveikatos mokslų universitetas-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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