Use this url to cite publication: https://hdl.handle.net/20.500.12512/13232
Options
Augmented renal clearance and its association with vancomycin serum level / Rima Minkutė, Vitalis Briedis, Rasa Steponavičiūtė, Astra Vitkauskienė, Romaldas Mačiulaitis
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Author(s)
Title
Augmented renal clearance and its association with vancomycin serum level / Rima Minkutė, Vitalis Briedis, Rasa Steponavičiūtė, Astra Vitkauskienė, Romaldas Mačiulaitis
Publisher (trusted)
Lietuvos sveikatos mokslų universitetas |
Date Issued
Date Issued |
---|
2012-11-24 |
Extent
p. 40-41 : pav.
Is part of
Achievements and development perspectives of pharmaceutical chemistry and other sciences : the international conference on pharmaceutical sciences and pharmacy practice dedicated to 125th Birth Anniversary of prof. Benediktas Šiaulis : book of abstracts : November 24, 2012 Kaunas, Lithuania / conference organizers : Vitalis Briedis, Eduardas Tarasevičius, Vilma Petrikaitė et al. ; Lithuanian University of Health Sciences. Kaunas : Lietuvos sveikatos mokslų universitetas, 2012. ISBN 978-9955-15-254-5.
Version
Originalus / Original
Series/Report no.
Abstracts of posters.
Description
Bibliogr.: p. 41
Field of Science
Keywords
Abstract
Background: Patients with serious infections require special attention to achieve successful treatment. One of significant factors influencing drugs effect is augmented renal clearance (ARC) – a new phenomenon in medicine, which is important for drugs eliminated via kidneys (1, 2). Vancomycin could serve as a model drug for which the presence of ARC might be clinically important as renal clearance pathway is completely dominating (2, 3). Objective of our study was (i) to determine ARC proportion among patients with estimated creatinine clearance (eCrCl) > 90 ml/min and tested for vancomycin serum concentration (VSC); (ii) to evaluate its impact on vancomycin dosage and serum concentration. Methods: In the retrospective study, all measurements of trough vancomycin serum concentration at steady state during a two years period were analysed. ARC and Control groups were formed (VSC in patients with eCrCl >130 ml/min and eCrCl 90-130 ml/min respectively). Appropriateness of measured VSCs to therapeutic level was evaluated. Results: ARC was identified in 50 % of patients included in analysis, and 38 VSCs for ARC and 39 VSCs for Control group were identified. ARC impact on VSC is presented in Fig. 1. Fig. 1. Appropriateness of measured trough vancomycin serum concentration to recommended level between the ARC (n = 38) and the Control (n = 39) groups, % (n). * p < 0.05; ARC – augmented renal clearance The relative risk for VSC subtherapeutic trough is higher in case of ARC (RR, 1.84; 95% CI, 1.23-2.74; P = 0.011). While reviewing prescribtion of vancomycin, the therapeutic dosage between 15 mg/kg/day and 30 mg/kg/day was detected for most patients in both groups, although dosage up to 15 mg/kg/day is noticeable for 40.4 % of patients in the Control group and dosage over 30 mg/kg/day for 13.2 % of patients in the ARC group. The dose distribution between dosage groups is comparable (Fig. 2) except group above 30 mg/kg/day, where vancomycin dose reached 44 mg/kg/da
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
978-9955-15-254-5
Other Identifier(s)
(LSMU ALMA)990000804320107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Affiliation(s)