Prognostic factors of short term outcome in severe ulcerative colitis flare

Abstract

Aim. To compare clinical, laboratorial and demographical parameters of patients who had severe ulcerativecolitis and achieved remission with medical therapy to those who failed to respond and had emergency colectomy. To identify the clinical, laboratorical and demographic parameters which could predict poorer course of illness (emergency colectomy). Methods. A retrospective study was held at the Lithuanian University of Sciences Gastroenterology Clinic. 55 patient's cases with severe ulcerativecolitis flare according to Mayo criteria during 2006-2011 years were analyzed. The first group of patients consisted individuals who achieved remission with medical therapy, second one included patients who failed to the same treatment and had to undergo emergency colectomy. Statistical analyzes was performed using SPSS ver. 19 software. For qualitative data analysis we used Chi-square parameter and for quantitative-Student parameter. Non parametric Mann-Whitney parameter was used for data comparisons. Along with that we performed logistic regression analysis to identify independent factors leading to a different outcome. For verification of statistical hypotheses, the significance level of (p<0.05) was chosen. [...].