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Assessment and comparison of corneal sub-basal nerve plexus morphology and corneal sensitivity in type 1 diabetic and non-diabetic patients / Irmante Derkac, Ingrida Januleviciene, Kirwan Asselineau, Dzilda Velickiene
Type of publication
Straipsnis kitame recenzuojamame leidinyje / Article in other peer-reviewed edition (S5)
Title
Assessment and comparison of corneal sub-basal nerve plexus morphology and corneal sensitivity in type 1 diabetic and non-diabetic patients / Irmante Derkac, Ingrida Januleviciene, Kirwan Asselineau, Dzilda Velickiene
Publisher (trusted)
Kugler Publications |
Date Issued
Date Issued |
---|
2016-06-15 |
Extent
p. 51-63.
Is part of
Journal for Modeling in Ophthalmology (JMO). Amsterdam : Kugler Publications, 2016, vol. 1, no. 1.
Version
Originalus / Original
Series/Report no.
Original article
Field of Science
Abstract
Aim/purpose: It is believed that small nerve bundles are damaged in the earliest stages of neuropathy caused by diabetes mellitus. Our goal was to evaluate and compare anatomical characteristics of corneal nerve fibers and corneal sensitivity in type 1 diabetes mellitus patients and in healthy control subjects. Design: cross-sectional study. Method: 30 patients with type 1 diabetes mellitus and 10 non-diabetic healthy subjects underwent a corneal confocal microscopy to evaluate the corneal sub-basal nerve fibers (density, number of nerves and branches, total nerve length) and contact corneal aesthesiometry. Results: Diabetic patients had significantly lower corneal nerve fiber density (14,32 ± 5,87 vs. 19,71 ± 5,59 mm/mm2 p=0,023 ), nerve branches number (4,57 ± 3,91 vs. 9,90 ± 5,8 n°/image, p=0,006) , nerve fiber length (2,28 ± 0,94 vs. 3,13 ± 0,89 mm, p=0,032) and corneal sensitivity (1,13 ± 0,29 vs. 0,98 ± 0,058 gr/mm2 p=0,02), as compared with controls. A negative correlation was found between corneal nerve fiber length, corneal nerve number, corneal nerve fiber density and diabetes duration (p<0,05). Conclusion: Corneal confocal microscopy and corneal sensitivity evaluation may help to evaluate early changes in the sub-basal nerve plexus typical to diabetic neuropathy in patients with diabetes mellitus. Further studies using corneal confocal microscopy as a novel noninvasive technique are needed to locate the earliest alterations in corneal nerves in patients with type 1 diabetes mellitus possibly predicting the development of neuropathy.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
2468-3922
Other Identifier(s)
(LSMU ALMA)990000900920107106
Coverage Spatial
Nyderlandai / Netherlands (NL)
Language
Anglų / English (en)
Bibliographic Details
28