Use this url to cite publication: https://hdl.handle.net/20.500.12512/22733
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Inhaled corticosteroids decrease cough reflex sensitivity to capsaicin in asthmatics but not in patients with COPD / Kristina Stravinskaite, Brigita Sitkauskiene, Peter V. Dicpinigaitis, Raimundas Sakalauskas
Type of publication
Tezės kitoje duomenų bazėje / Theses in other database (T1c)
Author(s)
Dičpinigaitis, Peter V | Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York | |
Title
Inhaled corticosteroids decrease cough reflex sensitivity to capsaicin in asthmatics but not in patients with COPD / Kristina Stravinskaite, Brigita Sitkauskiene, Peter V. Dicpinigaitis, Raimundas Sakalauskas |
Extent
p. 182s, no. P1084.
Is part of
European Respiratory Journal [elektroninis išteklius] : Abstracts : 18th ERS Annual Congress : Berlin, Germany October 4–8, 2008 / European Respiratory Society. , 2008, vol. 32, suppl. 52, October.
Version
Originalus / Original
Series/Report no.
Thematic Poster Session: Cough and airway hyperresponsiveness
Description
Aprasyta iš CD, yra ir internete.
Field of Science
Abstract
Cough is a common symptom in asthma and COPD. Few studies, yielding contrasting data, have evaluated the effect of inhaled corticosteroids (ICS) on cough reflex sensitivity in subjects with asthma and COPD. Aim of the study was to evaluate the effect of treatment with ICS on cough reflex sensitivity in patients with asthma and COPD. Methods: 25 patients with mild to moderate asthma and 27 with moderate to severe COPD were enrolled. None of the patients had used inhaled or oral corticosteroids for at least one month prior to the study. After baseline evaluation patients were randomized into groups: asthmatics – group 1 (n=15) treated with budesonide (400 mcg b.i.d) and salbutamol (200 mcg as-needed), group 2 (n=10) treated with placebo and salbutamol; COPD patients – group 3 (n=17) treated with budesonide (400 mcg b.i.d) and salbutamol (200 mcg as-needed) and group 4 (n=10) treated with placebo and salbutamol. All groups received four weeks of therapy. Capsaicin aerosol was given in order of ascending concentration until the concentrations inducing 2 or more (C2) and 5 or more coughs (C5) were attained. Results: after treatment, C5 significantly increased (i.e., cough reflex sensitivity decreased) in asthmatic subjects of group 1 (logC5 1.52±0.24; 2.08±0.22µM mean ± SEM p=0.020) but did not change in group 2 (logC5 2.13±0.33; 2.16± 0.32µM p=0.823). C2 did not significantly change in either asthma group. There were no significant changes in C2 and C5 after treatment in patients with COPD of group 3 and 4. Conclusion: Our data demonstrate that four weeks of therapy with ICS decreases cough reflex sensitivity to capsaicin in patients with asthma, but not in those with COPD.
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
0904-1850
Other Identifier(s)
(LSMU ALMA)990000712340107106
Coverage Spatial
Vokietija / Germany (DE)
Language
Anglų / English (en)