Use this url to cite publication: https://hdl.handle.net/20.500.12512/23139
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Adipocytokines, incretins, insulin resistance and body composition coherence in women with previously diagnosed gestational diabetes mellitus / Migle Francaite-Daugeliene & Dzilda Velickiene
Type of publication
Tezės kitoje duomenų bazėje / Theses in other database (T1c)
Title
Adipocytokines, incretins, insulin resistance and body composition coherence in women with previously diagnosed gestational diabetes mellitus / Migle Francaite-Daugeliene & Dzilda Velickiene
Publisher (trusted)
BioScientifica
Date Issued
2017-05-20
Extent
p. 288-288.
Is part of
Endocrine abstracts [elektroninis išteklius] : 19th European Congress of Endocrinology (ECE 2017) : 20-23 May, 2017, Lisbon, Portugal : abstract book / European Society of Endocrinology. Bristol : BioScientifica, 2017, vol. 49.
Version
Originalus / Original
Description
no. EP448
Eposter presentations.
Diabetes (to include Epidemiology, Pathophysiology).
Field of Science
Abstract
Introduction Adipose tissue is a major source of adipocytokines. It plays an important role for the development of insulin resistance (IR). Data implicate that incretins enhance insulin sensitivity. One aspect of the pathophysiology of gestational diabetes (GDM) is IR. The relationship between adipocytokines, incretins and GDM might be closely associated. Aim To evaluate the coherence of adipocytokines (adiponectin and leptin), incretins (GLP-1, GIP), insulin resistance and BMI in women with previously diagnosed GDM. Methods We examined 126 women with previously (16–43 years ago) diagnosed GDM. BMI, incretins, adipocytokines were evaluated. IR was calculated with HOMAIR index. Data expressed as meanGS.D. for parametric data or median (min–max) for non-parametric data. ANOVA was used to compare data between groups of three or more variables. Non-parametric data correlation analysis was performed using the Spearman’s correlation coefficient. The results were considered statistically significant at P!0.05. Results Women’s average age was 53.52G8.34 years (39–77 years). The coherence between adipocytokines, incretins and BMI was observed: increased BMI determined decreased adiponectin (rZK0.361, P!0.01), and increased leptin (rZ0.838, P!0.01) either incretins concentrations (GIP rZ0.270, PZ0.01 and GLP-1 rZ0.167, PZ0.21). HOMA-IR was higher in obese women (rZ0.641, P!0.01). Data analysed in different BMI categories (normal weight/overweight/ obese): adiponectin (26.8(12.2–76.8)/21.4 (10.8–54.4)/17.9 (5.2–41.6), P!0.01), leptin (5.9(0.2–16.1)/12.5(3.8–122.1)/24.7(11.1–74.9), P!0.01), GIP (0.8(0.2– 2.9)/0.97(0.2–5.2)/1.29(0.2–18.2), PZ0.145), GLP-1 (0.06(0.04–21.7) /0.06(0.04–6.1)/0.06(0.04–18.2), PZ0.517), HOMA-IR (2.2(0.5–4.7)/2.5(0.4– 6.4)/4.6(1.2–27.2), P!0.01). No significance between adiponectin and GIP, GLP-1 was defined (rZK0.152, PZ0.156/rZ0.02, PZ0.824). Women with l[...].
Is Referenced by
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1470-3947
1479-6848
Other Identifier(s)
(LSMU ALMA)990000936580107106
Coverage Spatial
Portugalija / Portugal (PT)
Language
Anglų / English (en)