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Regulation of myocardial calcium channels by cyclic AMP metabolism / Hove-Madsen L, Méry PF, Jurevicius J, Skeberdis AV, Fischmeister R
Type of publication
Straipsnis Web of Science duomenų bazėje / Article in Web of Science database (S1a)
Author(s)
Hove-Madsen, Leif | Université de Paris-Sud, France |
Mery, Pierre-François | Université de Paris-Sud, France |
Universite Paris-Sud, France | |
Universite Paris-Sud, Faculte de Pharmacie, France | |
Fischmeister, Rodolphe | Universite Paris-Sud, Chatenay-Malabry, France |
Title
Regulation of myocardial calcium channels by cyclic AMP metabolism / Hove-Madsen L, Méry PF, Jurevicius J, Skeberdis AV, Fischmeister R
Publisher (trusted)
Steinkopff |
Is Referenced by
Date Issued
Date Issued |
---|
1996-01-02 |
Extent
p. 1-8.
Is part of
Basic research in cardiology. Darmstadt : Steinkopff, 1996, vol. 91, suppl. 2.
Version
Originalus / Original
Field of Science
Abstract
Hormonal regulation of cardiac inotropism is often correlated with modification of the L-type Ca-channel current. Among several regulatory pathways that control Ca-channel activity, the best described one is the cAMP cascade. Cyclic AMP-dependent phosphorylation of the Ca-channel results in an increase of the mean open probability of the individual Ca-channels and, thus, of the macroscopic Ca current. Modulation of cAMP concentration can take place at the level of adenylyl cyclases or cAMP phosphodiesterases. Of major interest is the fact that the activity of two different forms of phosphodiesterases is controlled by the level of intracellular cGMP. Thus, cAMP metabolism is intimately associated with cGMP metabolism, and both determine the degree of cAMP-dependent phosphorylation of cardiac Ca-channels. This brief discussion will focus on these two levels of control and their relative importance in the cAMP-dependent regulation of myocardial Ca-channels.
Type of document
type::text::journal::journal article
ISSN (of the container)
0300-8428
WOS
A1996VX75100002
Other Identifier(s)
(LSMU ALMA)990000419100107106
Coverage Spatial
Vokietija / Germany (DE)
Language
Anglų / English (en)
Bibliographic Details
90