An Influence of hyperglycemia and smoking on lipid peroxidation level in blood serum of middle-aged men
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2006 |
The aim of this work - to evaluate the influence of hyperglycemia and cigarette smoking on blood serum lipid peroxidation level in middle-aged men. Subject and methods. In this work we have used data of 360 men aged 35-64 years from Kaunas city population cohort investigated according to MONICA study protocol during 2001-2002. Lipid peroxidation marker serum concentration of malondialdehyde (MDA) was measured by fluorimetrical method. Increased level of lipid peroxidation was evaluated as MDA≥5.0 μmol/l. Glucose concentration was determined in capillar blood by individual glucometer. Hyperglycemia was evaluated as fasting glucose ≥6.1 mmol/l. Information on smoking habits was obtained with the use of a standard questionnaire. Results. After distribution of men into three 10 years age groups (35-44, 45-54, 55-64) MDA concentration and the rate of increased MDA level in every age group in men with hyperglycemia was slightly higher than in men without hyperglycemia. In every age group in current smokers MDA was higher than in never-smokers in every age group and significantly higher in 35-44 and 45-54 years groups. Hyperglycemia was more associated with increased MDA level in never-smokers than in current smokers for men aged 45-64 years. In comparing of MDA level in four subgroups of men aged 35-64 years according glucose level and smoking habits, the highest rate of increased MDA level was detected in persons with two risk factors - current smokers with hyperglycemia (56%). The rates of increased MDA level in subgroups with one risk factor - in current smokers without hyperglycemia and in never-smokers with hyperglycemia were 48.1% and 37.5% respectively. The lowest rate of increased MDA level was detected in men without those risk factors - in never-smokers without hyperglycemia (25.8%) (OR were 3.66, 2.67, 1.73 and 1.0 respectively).