Relationship of hyperglycemia with other components of metabolic syndrome among middle-aged persons in relation with gender and age

Every component of metabolic syndrome (MetS) is a risk factor of ischemic heart disease (IHD). In our population the risk of mortality from IHD of persons with MetS and hyperglycemia was higher than of persons with MetS and without hyperglycemia. The aim of the study was to evaluate the association of fasting hyperglycemia with every component of MetS in relation with gender and age. Methods: The health survey according to the WHO MONICA study (MONItoring of trends and determinants in CArdiovascular disease) protocol was carried out in Kaunas city (Lithuania) from 2001 to 2002. A random sample of subjects aged 35 to 64 years was selected. The sample was stratified by age and sex so that at least 200 men and women would be screened in every 10-years age group (35--44, 45--54, 55--64). A total of 1403 persons were screened (626 men and 777 women: response rate 62.4%). In this work we analyzed data from 1336 subjects (603 men and 733 women cohort from Kaunas city population) aged 35 to 64 years for whom there were complete data of all five MS components. MetS components were evaluated according to ATP III criteria: hyperglicemia (concentration of fasting glucose Z6.111 mmol/l), raised blood pressure (BP) (systolic/diastolic BPZ130/855mmHg), central obesity (waist circumference <102/88 cm, for men/women), raised triglycerides (TG) level (TGZ1.777 mmol/l), reduced high density lipoprotein (HDL) cholesterol level (>1.04/1.333mmol/l for men/women). Results: Among persons with hyperglycemia in relation with persons without hyperglycemia: (1) the rate of raised BP was significantly higher in men and women aged 35--44 and 45--54 years (in men - OR 3.39, 3.38 respectively ; in women - OR 5.29, 2.72 respectively); (2) the rate of central obesity was significantly higher in men and women aged 35--44, 45--54 and 55--64 years (in men - OR 5.68, 5.09, 3.43 respectively; in women – OR 4.23, 3.59, 3.96 respectively); (3) the rate of raised TG was significantly higher in men.