An association of diabetes or hyperglycemia and increased level of lipid peroxidation with stroke and myocardial infarction in elderly men
Stroke is a deadly and disabling disease that preferentially afflicts older adults; it shares common risk factors with myocardial infarction (MI), such as diabetes and oxidative stress. The aim of this work: To evaluate the association of stroke and MI with diabetes, hyperglycemia and increased level of lipid peroxidation in elderly men from Kaunas urban population investigated in 1995-1996. Subjects and methods: In this work we used data of 525 men aged 65-84 years. Previous stroke and MI were determined according to epidemiological criteria. History of stroke was based on answers to following interview question: "Has a doctor ever told you that you had a stroke?". Previous MI was determined according to answers of responders to question: "Has a doctor ever told you that you had a heart attack?" and/or changes on electrocardiogram coded by Minnesota codes as 1-1 or 1-2. All stroke and MI cases were verified using all possible medical documentation (hospital discharge records, domiciliary care records of outpatient departments and etc.). 30 men had stroke, 65 men had MI. Diabetes mellitus was determined by persons answer to question: "Has a doctor ever told that you have diabetes?" and/or glucose level =11.111 mmol/l after 2 hour glucose laod (75 g). Glucose concentration was determined in capillar blood by individual glucometer. Hyperglycemia was evaluated as fasting glucose =6.111 mmol/l. Lipid peroxidation marker malondialdehyde (MDA) was measured by fluorimetrical method and increased level was evaluated as =5.5 micromol/l. Results: The average of age for men who had stroke or MI (N=89) was not different to age for men without stroke or MI (N=436): 73.5±4.64 years and 72.9±4.10 years respectively (p>0.05). Among men who had stroke or MI the rate of diabetes or hyperglycemia (a) and the rate of increased level of MDA (b) were significantly higher than among men without stroke and MI (1.8 and 1.4 times accordingly): (a) 25.8% vs. 14.7% (p<0.05), (b) 46.6.