Use this url to cite publication: https://hdl.handle.net/20.500.12512/85096
Kompiuterinis fosfodiesterazių slopinimo 1-acil-2-alkiltiobenzimidazolais tyrimas
Type of publication
Straipsnis nerecenzuojamoje Lietuvos konferencijos medžiagoje / Article in non-peer-reviewed Lithuanian conference proceedings (P2c)
Author(s)
| Author | Affiliation |
|---|---|
Mikulskis, P | |
Title
Kompiuterinis fosfodiesterazių slopinimo 1-acil-2-alkiltiobenzimidazolais tyrimas
P. Mikulskis, A. Brukštus, L. Labanauskas, V. Garalienė, V. Kairys, M.X. Fernandes
Other Title
Computer guided study of phosphodiesterases inhibitors 1-acyl-2-alkylthiobenzimidazoles.
Date Issued
| Date |
|---|
2008-04-16 |
Extent
p. 14-15.
Is part of
Organinė chemija : mokslinės konferencijos pranešimų medžiaga = Organic chemistry : proceedings of scientific conference / Kauno technologijos universitetas. Kaunas : Technologija, 2008. ISBN 9789955254713.
Version
Originalus / Original
Description
Bibliogr.: p. 15 (7 pavad.).
Field of Science
Abstract (lt)
A series of 1-acyl-2-alkylthiobenzimidazole compounds were docked into several phosphodiesterase isoforms. The docking results show no correlation with the experimentally measured inotripic effect. This could be explained by several factors: experimental ED50 and computed free energies may not be directly correlated; experimental data were obtained using tissue, which contains more than one isozyme of PDE, and computer data were computed individual isoforms; structures of phohodiesterases may be different in human and guinea pig.
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9789955254713
Other Identifier(s)
(LSMU ALMA)990000709310107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Lietuvių / Lithuanian (lt)