Use this url to cite publication: https://hdl.handle.net/20.500.12512/86428
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Interleukin-1B and IL1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis / L. Kupcinskas, T. Wex, J. Kupcinskas, G. Kiudelis, L. Jonaitis, D. Janciauskas, A. Ivanauskas, A. Sudraba, K. Funka, H. Chiu, M. Leja, J. Lin, P. Malfertheiner
Type of publication
Tezės Web of Science duomenų bazėje / Theses in Web of Science database (T1a1)
Author(s)
Wex, Thomas | Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany |
Sudraba, Agnese | Faculty of Medicine, University of Latvia, Riga, Latvia |
Funka, Konrads | Faculty of Medicine, University of Latvia, Riga, Latvia |
Chiu, Han-Mo | National Taiwan University Hospital, Taipej, China |
Leja, Mārcis | Faculty of Medicine, University of Latvia |
Lin, Jaw-Town | National Taiwan University Hospital, Taipej, China |
Malfertheiner, Peter | Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany |
Title
Interleukin-1B and IL1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis / L. Kupcinskas, T. Wex, J. Kupcinskas, G. Kiudelis, L. Jonaitis, D. Janciauskas, A. Ivanauskas, A. Sudraba, K. Funka, H. Chiu, M. Leja, J. Lin, P. Malfertheiner
Publisher (trusted)
Wiley-Blackwell Science
Date Issued
2010-09-16
Extent
p. 323, no. W4.4.
Is part of
Helicobacter : XXIII International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer : Rottrrdam, September 16-18, 2010 : Abstracts / European Helicobacter Study Group. Cambridge, MA : Wiley-Blackwell Science, 2010, vol. 15, no. 4, August.
Version
Originalus / Original
Series/Report no.
Abstracts.
Abstracts.
Description
Impact Factor: 2.851.
Field of Science
Abstract
Objective: Contradictory results have been reported about the role of interleukin-1B (IL1B) and IL1 receptor antagonist (IL1RN) alleles in gastric carcinogenesis. Here, IL1B and IL1RN polymorphisms were analyzed as geno- and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia (IM) in the stomach. Methods: Two-hundred-seventy-eight patients (212 Caucasians and 66 Asians) aged 50 years and older, referred for upper endoscopy due to dyspeptic symptoms, were included. Gastric biopsies were histologically assessed according to the updated Sydney classification. Genomic DNA was typed for polymorphisms at position -3737, -1464, -511, -31 for the IL1B gene and the allele 2 of IL1RN using restriction fragment length polymorphism of amplified PCR fragments and intron-spanning PCR analysis, respectively. Results: IL1B-1464-C/C genotype was associated with higher presence of AG in antrum of the stomach in Caucasians [OR: 4. 8 (95% CI = 1.7–14.3); p = 0.028]. IL1B-1464-G/C genotype was associated with lower incidence of AG in corpus of the stomach in Asians [OR: 0.7 (95% CI = 0.5–0.8); p = 0.02]. IL1RN*2 allele was not linked with AG or IM [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1083-4389
Other Identifier(s)
(LSMU ALMA)990000735050107106
Coverage Spatial
Nyderlandai / Netherlands (NL)
Language
Anglų / English (en)
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
HELICOBACTER | 3.109 | 3.587 | 3.568 | 3.606 | 2 | 0.868 | 2010 | Q2 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
HELICOBACTER | 3.109 | 3.587 | 3.568 | 3.606 | 2 | 0.868 | 2010 | Q2 |