Comprehensive genetic analysis of multiple inflammatory bowel disease susceptibility markers in the Lithuanian and Latvian patient populations
| Author | Affiliation |
|---|---|
Irnius, Algimantas | |
Denapienė, Goda | |
Valantinas, Jonas | |
Balschun, Tobias | Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany |
Leja, Mārcis | Digestive Diseases Centre GASTRO, University of Latvia, Riga, Latvia |
Derovs, Aleksejs | Paula Stradina University Hospital, Riga, Latvia |
Schreiber, Stefan | Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany |
Franke, Andre | Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany |
| Date |
|---|
2010-10-23 |
Impact factor: 9.357.
Introduction/Objectives: Inflammatory bowel diseases (IHB) a chronic gastrointestinal inflammatory disorder with a complex genetic background, most commonly presents as either one of the two subtypes, ulcerative colitis (UC) or Crohn's disease (CD). The number genetic variations conferring to IBD susceptibility increased over the past few years after the introduction of genome-wide association scans (GWAS). Although several susceptibility loci have been replicated, some of the associations have been reported to be unique for certain ethnicities. Aims and Methods: To perform a comprehensive association analysis of genetic markers in the Lithuanian and Latvian IBD patient sample set. The large replication study was performed using 582 Lithuanian and Latvian IBD patients (139 CD and 443 UC) and 1157 controls. [...].