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Value of gastrin-17 in detecting antral atrophy / Leja M, Kupcinskas L, Funka K, Sudraba A, Jonaitis L, Ivanauskas A, Janciauskas D, Kuidelis G, Chiu HM, Lin JT
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Leja, Marcis | University of Latvia, Riga, Latvia |
Funka, Konrads | University of Latvia, Riga, Latvia |
Sudraba, Agnese | University of Latvia, Riga, Latvia |
Chiu, Han-Mo | National Taiwan University Hospital, Taipei, Taiwan, Republic of China |
Lin, Jaw-Town | National Taiwan University Hospital, Taipei, Taiwan, Republic of China |
Title
Value of gastrin-17 in detecting antral atrophy / Leja M, Kupcinskas L, Funka K, Sudraba A, Jonaitis L, Ivanauskas A, Janciauskas D, Kuidelis G, Chiu HM, Lin JT
Publisher (trusted)
Medical University of Białystok |
Is Referenced by
EMCARE |
DOAJ |
DOAJ |
FSTA |
Food Science and Technology Abstracts |
IBIDS |
Date Issued
Date Issued |
---|
2011-02-01 |
Extent
p. 145-150.
Is part of
Advances in medical sciences. Warsaw : Versita, 2011, vol. 56, no. 2.
Version
Originalus / Original
Series/Report no.
Original article
Field of Science
Keywords
Abstract
Purpose: Decreased plasma gastrin-17 (G-17), particularly after protein stimulation, is indicative of atrophy in the antral stomach mucosa. Available data on the value of this biomarker is inconclusive. Our study was aimed to evaluate the performance of the G-17 test in Caucasian and Asian patients for antral atrophy evaluation either in fasting state or after protein stimulation. Material/Methods. 241 dyspeptic patients aged 55 and above from Latvia (125), Lithuania (76) and Taiwan (40) were enrolled. G-17 levels were detected in plasma samples obtained either during fasting or after a protein-rich test meal. Levels <1pmol/L at fast and <5 pmol/L after stimulation were considered indicative of atrophy. Results. The sensitivity of the test was 15.8%, its specificity 88.7%, and the overall accuracy 83% in the fasting state, and 36.8, 86.5, and 82.6%, respectively, after stimulation. In the Caucasian subgroup, the corresponding figures were 15.4, 91.5, and 86.6% in the fasting state and 30.8, 92.6, 88.6% after stimulation; but for the Asian subgroup the corresponding figures were 16.7, 73.5, and 65% (fasting) and 50, 52.9, and 52.5% (stimulated). Conclusions. The performance of G-17 was better after protein stimulation. G-17 was highly specific in the Caucasian, but not in the Asian subgroups. Still the low test sensitivity either at fast or following protein stimulation does not allow us to recommend it for wide screening purpose to diagnose antral atrophy.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
1896-1126
WOS
000300097400004
Other Identifier(s)
(LSMU ALMA)990000770510107106
Coverage Spatial
Lenkija / Poland (PL)
Language
Anglų / English (en)
Bibliographic Details
25
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Advances in Medical Sciences | 0.952 | 3.221 | 3.221 | 3.221 | 1 | 0.296 | 2011 | Q4 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
Advances in Medical Sciences | 0.952 | 3.221 | 3.221 | 3.221 | 1 | 0.296 | 2011 | Q4 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Advances in Medical Sciences | 1.6 | 0.598 | 0.362 | 2011 | Q3 |