Use this url to cite publication: https://hdl.handle.net/20.500.12512/89793
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A novel cellulose – hydroxyapatite scaffold for bone tissue regeneration / Povilas Daugela, Gintaras Juodzbalys, Jolanta Liesiene, Odeta Petrauskaite, Pedro Gomes, Elisabete Costa
Type of publication
Tezės Web of Science duomenų bazėje / Theses in Web of Science database (T1a1)
Author(s)
Liesienė, Jolanta | Kauno technologijos universitetas |
Petrauskaitė, Odeta | Kauno technologijos universitetas |
Gomes, Pedro de Sousa | University of Porto, Porto, Portugal |
Costa, Elisabete | Department of Ceramics and Glass Engineering, CICECO, University of Aveiro, Portugal |
Title
A novel cellulose – hydroxyapatite scaffold for bone tissue regeneration / Povilas Daugela, Gintaras Juodzbalys, Jolanta Liesiene, Odeta Petrauskaite, Pedro Gomes, Elisabete Costa
Publisher (trusted)
Munksgaard International Publishers
Date Issued
2012
Extent
p. 230, no. 498.
Is part of
Clinical oral implants research : EAO 18th annual scientific meeting : abstracts / European association for osseointegration ; Editor-in-chief: Niklaus P. Lang ; Asociate editors: T. Berglundh, G.E. Salvi, H.P. Weber. Copenhagen : Munksgaard International Publishers, 2012, vol. 23, suppl. 7, October.
Version
Originalus / Original
Series/Report no.
Posters – Tissue Augmentation and Engineering.
Field of Science
Abstract
Background: Nowadays much attention is focused on polymerceramic three-dimensional scaffolds for bone tissue regeneration in defect site. For a successful performance the ideal scaffold should be a 3D interconnected porous structure able to promote cell adhesion, proliferation and vascularisation, while enabling a controlled supply of bioactive substances that might influence the behaviour of incorporated or ingrown cells. Aim: To investigate a novel cellulose-based porous composites with hydroxyapatite for the bone scaffold. Methods: The composites were fabricated by saponification of diacetylcellulose adding hydroxyapatite. After the reaction the obtained gel of regenerated cellulose was homogeneously immobilized with hydroxyapatite. In order to create suitable matrix the composites were freeze-dried. Results: It was found out that the conditions of lyophilisation highly influenced the morphology of the matrix. The porosity of the scaffolds was up to 75% with pores of different sizes up to 770 lm. The results of bioactivity test in vitro showed that bone-like apatite appeared onto the surface after 7 days of immersion in simulated body fluid. Furthermore, the behaviour of MG-63 human osteoblastic-cells on investigated cellulose matrix was examined. It was found that the scaffolds are not cytotoxic and induce the growth of the cells. Conclusions and clinical implications: From the obtained results it could be concluded that prepared scaffolds have a great potential for bone tissue ingrowth in vivo. Attained results substantiate the suitable application of cellulose/hydroxyapatite scaffolds in bone tissue engineering applications.
Is Referenced by
Current Contents / Clinical Medicine
Science Citation Index
SciSearch
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
0905-7161
Other Identifier(s)
(LSMU ALMA)990000802930107106
Coverage Spatial
Danija / Denmark (DK)
Language
Anglų / English (en)
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
CLINICAL ORAL IMPLANTS RESEARCH | 3.433 | 2.304 | 1.739 | 2.869 | 2 | 1.595 | 2012 | Q1 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
CLINICAL ORAL IMPLANTS RESEARCH | 3.433 | 2.304 | 1.739 | 2.869 | 2 | 1.595 | 2012 | Q1 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Clinical Oral Implants Research | 5.7 | 2.222 | 3.119 | 2012 | Q1 |