Use this url to cite publication: https://hdl.handle.net/20.500.12512/91784
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The Effects of natural antioxidants on process of complications in patients with type 2 diabetes / Nijole Savickiene, Asta Spadiene, Andrejs Skesters, Alise Silova, Antanas Norkus, Rytas Ostrauskas, Smigle Francaite–Daugeliene
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Author(s)
Šķesters, Andrejs | Riga Stradinš university |
Silova, Alise | Riga Stradinš university |
Title
The Effects of natural antioxidants on process of complications in patients with type 2 diabetes / Nijole Savickiene, Asta Spadiene, Andrejs Skesters, Alise Silova, Antanas Norkus, Rytas Ostrauskas, Smigle Francaite–Daugeliene
Publisher (trusted)
Vytauto Didžiojo universitetas
Date Issued
2014
Extent
1 skelb., p. 27, no. L-16.
Is part of
The Vital Nature Sign [elektroninis išteklius] : 8th International Scientific Conference The Vital Nature Sign : Abstract book / Vytautas Magnus University ; [Scientific Committee: P. Audrius Maruška, Algimantas Paulauskas, Stellan Hjerten et al. ; Organizing Committee Chairman/Editor: Audrius Maruška]. Kaunas : Vytautas Magnus University, 2014.
Version
Originalus / Original
Description
Bibliogr.: p. 27
Field of Science
Abstract
In this study (International “Eureka“ project E! 3695 „Creation of the methodology for effects of natural antioxidants on the development of the Diabetes mellitus complications“) we evaluated the effects of Ginkgo biloba L. and Camellia sinensis L. leaves extracts on oxidative damage in type 2 diabetic patients with surrounding diabetic complications (neuropathy, nephropathy, rethinophaty) [1]. All subjects (88 patients) were outpatients of the Endocrinology Clinic, Hospital of Lithuanian University of Health Sciences Kaunas Clinics. Subjects diagnosed with type 2 diabetes mellitus (treated with Insulinum, Metforminum or combination of both), aged from 35 to 80 years old and followed up for diabetic retinopathy, nefropathy or neuropathy were enrolled into the study. All patients were randomly allocated to receive standardized Ginkgo biloba dry extract (Ex.Gb), Ex.Cs (standardized Camellia sinensis L. leaves extract), compound of both extract - Grinvitals Cereloba plus tablets (GCP) or placebo capsules. The baseline measurements were repeated after 9 and 18 months of receiving preparations. First nine months patients received capsules twice a day, second nine months – three times a day. Placebo capsules were made from microcrystalline cellulose, a material indifferent to disease. The comparisons between three different measurements (at baseline, after 9 and 18 months) were made using Friedman test and Two-way ANOVA. The results were considered statistically significant at p < 0.05. The results confirm the beneficial influence of Ex.Gb on reducing amount of MDA (malondialdehyde) and HNE (4-hydroxy-2-nonenal) in diabetic patients. The strongest effect of Ex.Gb was observed on the amount of lipid peroxidation markers. While the Ex.Cs didn’t have significant effects. Ex.Gb had the most influence on perivascular changes (perivascular intumescence, haemorrhages, accumulation of hemosiderin, lipid infiltration of conjunctiva) in bulbar conjunctiva vessel
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
2335-8653
Other Identifier(s)
(LSMU ALMA)990000843510107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)