Adrenal androgen producing adenoma associated with epileptic seizures

Abstract

Romanian Academy The Publishing House of the Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938 in ISI Thomson Master Journal List Year 2014 / Contents: July - September 2014, Issue 3 July - September 2014, Volume 10, Issue 3 Case Report This Article [Full Text] Submit a related Letter to the Editor Services Email this article to a friend Google Scholar Articles by Matulevicius V Articles by Urbanavicius V PubMed Articles by Matulevicius V Articles by Urbanavicius V Acta Endocrinologica (Buc) Articles by Matulevicius V Articles by Urbanavicius V Matulevicius V, Ostrauskas R, Krasauskas V, Verkauskiene R, Ciaplinskiene L, , Urbanavicius V Adrenal Androgen Producing Adenoma Associated with Epileptic Seizures Acta Endo (Buc) 2014, 10 (3): 487-494 doi: 10.4183/aeb.2014.487 Background. Dehydroepiandrosterone sulphate (DHEA-S) is a major steroid product of adrenal glands and an important neurosteroid, but due to only slight androgenic activities pathology of DHEA-S secretion it was rarely described until now. Aim. To report a case of DHEA-S and testosterone secreting adrenal tumour with clinical manifestations of suddenly appeared epileptic seizures, amenorrhea, hirsutism, weight gain and decreased sexual activity before operation, and up to 12 months observation after surgical removal of the tumour. Methods. Presentation of clinical case with comments. Results. Epileptic seizures, amenorrhea, weight gain and hirsutism suddenly appeared in a 38-year-old fertile woman. A right adrenal tumour was detected. Blood levels of DHEA-S and testosterone were very high. Surgical removal of the adenoma (confirmed histologically) was performed what conditioned decrease of DHEA-S, testosterone and other hormones in 2-24 hours for the level of adrenal insufficiency. [...].