Use this url to cite publication: https://hdl.handle.net/20.500.12512/94187
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Control of the porous structure of cellulose-based tissue engineering scaffolds by means of lyophilization / Odeta Petrauskaite, Gintaras Juodzbalys, Pranas Viskelis, Jolanta Liesiene
Type of publication
Straipsnis Web of Science duomenų bazėje / Article in Web of Science database (S1a)
Author(s)
Petrauskaitė, Odeta | Kauno technologijos universitetas |
Viškelis, Pranas | Lietuvos agrarinių ir miškų mokslų centro filialas Sodininkystės ir daržininkystės institutas |
Liesienė, Jolanta | Kauno technologijos universitetas |
Title
Control of the porous structure of cellulose-based tissue engineering scaffolds by means of lyophilization / Odeta Petrauskaite, Gintaras Juodzbalys, Pranas Viskelis, Jolanta Liesiene
Publisher (trusted)
Academia Republicii Socialiste Romania
Date Issued
2016-02-15
Extent
p. 23-32.
Is part of
Cellulose chemistry and technology. Bucharest : Academia Republicii Socialiste Romania, 2016, vol. 50, no. 1.
Version
Originalus / Original
Description
The work was supported by grant MIP-019/2014 from the Research Council of Lithuania.
Field of Science
Abstract
The porous structure of tissue engineering scaffolds that serve as templates for bone tissue regeneration must be precisely designed as it is related to cell adhesion, proliferation, differentiation and vascularization. In this work, the morphology of a three-dimensional matrix of regenerated cellulose prepared by the freeze-drying method was studied. The regenerated cellulose-based gel was obtained by saponification of cellulose acetate. Lyophilization was chosen to create a highly porous matrix with an optimal pore size required for successful bone regeneration. It was found that the porous structure of the gel depended on the solution in its discontinuous phase prior to the drying process. By changing the concentration of ethanol in the discontinuous phase, the morphology of the lyophilized matrix varied from macroporous to dense. The matrix of the desired morphology with micro and macro pores was obtained by lyophilization of the gel, which was filled with 20% of ethanol solution in water and pre-frozen at -25ºC. The cellulose based matrix showed a permeable pore network for glucose, thus substantiating its suitability for the fast diffusion of nutrients.
Is Referenced by
Type of document
type::text::journal::journal article
ISSN (of the container)
0576-9787
WOS
000376831900003
Other Identifier(s)
(LSMU ALMA)990000891390107106
Coverage Spatial
Rumunija / Romania (RO)
Language
Anglų / English (en)
Bibliographic Details
43
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
CELLULOSE CHEMISTRY AND TECHNOLOGY | 0.763 | 1.437 | 1.437 | 1.437 | 1 | 0.531 | 2016 | Q3 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
CELLULOSE CHEMISTRY AND TECHNOLOGY | 0.763 | 1.437 | 1.437 | 1.437 | 1 | 0.531 | 2016 | Q3 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Cellulose Chemistry and Technology | 1.3 | 0.596 | 0.33 | 2016 | Q3 |