Please use this identifier to cite or link to this item:
Type of publication: conference paper
Type of publication (PDB): Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Medicina / Medicine (M001)
Author(s): Francaitė-Daugėlienė, Miglė;Veličkienė, Džilda
Title: Adipocytokines, insulin resistance and obesity coherence in women with previously diagnosed gestational diabetes
Is part of: DEXEUS 2016 : 43 International Forum focusing on issues in Women's health "Update in Obstetrics, Gynaecology and Reproductive Medicine" : Barcelona, Spain, October 26-28, 2016 / Dexeus Women's Health Foundation. Barcelona : ComtecMed, 2016
Extent: p. 1-1, no 19
Date: 2016
Series/Report no.: (Obstetrics)
Keywords: Diabetes, gestational;Adipokines;Insulin resistance;Obesity
Abstract: Introduction: Adipose tissue is a major source of adipocytokines. It plays an important role for the development of insulin resistance(IR). One aspect of the pathophysiology of gestational diabetes(GDM) is also IR. The relationship between adipocytokines and GDM might be closely associated. Aim: To evaluate the coherence of body composition with adipocytokines (adiponectin and leptin) and IR in women with previously diagnosed GDM. Methods: We examined 80 women with previously (16-43 years ago) diagnosed GDM. BMI was evaluated. Fasting plasma glucose(FPG) was examined for women with diabetes mellitus(DM). Oral glucose tolerance test was performed to evaluate the carbohydrate metabolism for the rest. Leptin and adiponectin were evaluated for fat metabolism assessment. IR was calculated with HOMA-IR index. The results were considered statistically significant at p0.05. Results: Women during the investigation period were 55.14±8.26years (39-77years). Strong correlation between adipocytokines and BMI was observed: increased BMI determined decreased adiponectin (r=-0.304;p=0.006), and increased leptin concentrations (r=0.871;p0.001). The mean of adiponectin concentration was 27.48±15.05 in women with normal BMI (N=21) and 21.26±7.65 in overweight women (N=17). The mean of leptin concentration was 6.93±4.55 in normal BMI women; 11.74±4.48 in overweight. The mean of adiponectin and leptin concentrations in obese women were respectively: Iº obesity (N=17) - 19.12±9.84; 19.41±6.05, IIº obesity (N=13) - 18.06±6.19; 23.62±7.74, IIIº obesity (N=12) 16.07±6.4; 49.0±17.72. No significance between adiponectin and insulin concentrations was defined. Strong correlation between leptin and insulin concentration (r=0.624, p0.001) either IR (r=0.489; p=0.03) was observed. The positive correlation between leptin and FPG (r=0.336; p=0.004) was found. No other significant difference between adipocytokines and carbohydr. [...]
Affiliation(s): Cukrinio diabeto laboratorija
Lietuvos sveikatos mokslų universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

Show full item record
Export via OAI-PMH Interface in XML Formats
Export to Other Non-XML Formats

Page view(s)

checked on Mar 30, 2020


checked on Mar 30, 2020

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.