Neuroleptinis maligninis sindromas

Abstract

Neuroleptinis maligninis sindromas (NMS) retas, bet da niausiai mirtinas neuroleptikų sukeltas sindromas su hipertermija, pakitusia sąmone, ekstrapiramidiniais pokyčiais, autonominiu nestabilumu, raumenų rigidi kumu. Ap valginiame straipsnyje analizuojama io sindromo patofiziologija, da nis, eiga, baigtis, mir tamumas ir gydymas tiek ikihospitaliniu laikotarpiu, tiek intensyviosios terapijos skyriuje. Straipsnyje diskutuojama apie io sindromo simptomus, diferencinę diagnostiką bei profilaktiką. The neuroleptic malignant syndrome (NMS) is a rare but potentially lethal form of neuroleptic drug-induced hyperthermia, altered level of consciousness, extrapyramidal effects, autonomic instability and muscle rigidity. The present review decribes pathophysiology, frequency, course, outcome, mortality and management of NMS in prehospital care and emergency department care. Review discusses clinical features, diagnosis differentiation of this hyperpyretic rigidity syndrome from other disorders and prevention of this serious iatrogenic condition as life threatening disorder.