Modeling of Gels with Salicylic Acid and Cannabis Seed Oil for the Treatment of Acne Vulgaris

Abstract

Lately, acne vulgaris has become one of the most spread skin diseases. On the basis of the global spread of diseases project data, it was determined that 9.4% of the global population develop acne. So, acne takes 8th place in the world according to its spread (Tan & Bhate, 2015). A course of the disease is usually long, therefore it is actual to choose safe daily skin care means in order to alleviate signs of acne and improve skin condition (Bartenjev et al., 2011). Antibiotics are widely applied in acne treatment, either. The use of antibiotics, however, may promote the emergence and spread of bacterial resistance. That stimulates the scientists to seek new antiseptic and antimicrobial preparations for local treatment of skin infections. The main goal of treatment for acne vulgarisis to prevent the emergence of new acne and to gradually treat them by choosing the right cosmetics or medications. The topical treatment is forthe treatment of mild to moderate acne. The process of treating acne is time-consuming, so it is important to choose safe daily skincare products to reduce the signs of acne and improve the condition of the skin (Bartenjev et al., 2011). The need for natural products also encourages the search for natural excipients in the production of gels. One such gelatin is chitosan. In our study, salicylic acid was selected as the active ingredient. Salicylic acid promotes the synthesis of skin collagen and elastin, smooths scars, reduces skin pigmentation, reduces skin oiliness, suppresses inflammatory reactions, and cleans clogged pores. Given that salicylic acid does not have moisture-retaining properties, it is important to introduce an additional component to protect the skin from moisture loss. Cannabis oil was selected as an antibacterial, moisture-restoring component in the modeling of gels with salicylic acid. [...].