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A Relationship between osteocalcin and acute myocardial infarction
Hedayat, Kamyar | Research, Systems Biology Research Group, Chicago, USA |
Date Issued |
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2019-08-05 |
ISBN 978-9955-15-620-8.
Introduction. Physical (pain, myocardial necrosis, impaired heart muscle function) and psychological (fear of dying, helplessness and etc.) stress experienced during acute myocardial infarction (AMI) are activated neurohormonal systems in the early phase of acute coronary syndrome. Osteocalcin (OC) is a hormone and non-collagenous, vitamin K dependent peptide found in the mineralized matrix of bone. As a hormone, OC effects on energy metabolism regulation. Acutely ischemic heart is associated with dramatic alterations in cardiac energy metabolism. Research aim. To assess the relationship between serum osteocalcin concentration and AMI. Research methods and organization. One-hundred-twelve patients (mean age 63.9±11.6 years) admitted due to AMI with no previous history of acute coronary syndrome, revascularization, receiving all types of steroids and hypo- or hyperthyroidism between April 2017 and November 2017 have been prospectively included into our single centre study. AMI was defined according to the Universal Definition of Myocardial Infarction. Blood samples were drawn during admission. Blood was taken from patients 15 min after bed rest. Serum calcium was determined using UniCel DxC 800 Synchron Clinical System (Beckman Coulter Inc, Fullerton, USA) following manufacturer recommendations. Serum osteocalcin was measured using ELISA (enzyme – linked - immunoassay) kits (Micro Vue, Quidel, Hanover, Germany). Statistical analysis was conducted using SPSS version 21. Chi-squared, Spearman, and logistic regression tests were used for analysis. Results. The OC level was normal in 79.7% (n = 98) patients, while it was elevated in 11.4% (n = 14) of the patients. The calcium level was normal in 65.9% (n = 81) of the patients, while decreased in 31.7%..