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Activity of statins in pancreatic cancer cell lines
Date Issued |
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2017-04-28 |
Statins, also known as 3-hydrooxy-3-mehylglutaryl coenzyme A reductase (HMG-CoA) inhibitors, are class of medicines that are used to treat hypercholesterolemia by inhibiting cholesterol synthesis. Also, they have been widely investigated because of their possible anticancer activity. Recent studies show, that they excert antineoplasic effects againt multiple types of cancer, such as breast, colorectal and prostate cancer or glioblastoma. The aim of our study was to evaluate activity of four statins (lovastatin, simvastatin, mevastatin and pitavastatin calcium) against pancreatic cancer which has the highest mortality rates of all major cancer types. Effect of statins on cell viability was evaluated by MTT assay in three monolayer cultured pancreatic cancer cell lines: BxPC-3, MIA PaCa-2, Panc-1. Also, 3D cell cultures were formed using 3D Bioprinting method and the activity of statins was examined by measuring the size change of spheroids. [...].