Use this url to cite publication: https://hdl.handle.net/20.500.12512/10024
Options
CUGB2 expression changes in pancreatic cancer cell lines (SU86, T3M4 and CAPAN1) treated with indomethacin
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Author(s)
Markovskaja, Viktorija | |
Markovskij, Nikolaj | |
Plenta, Dainius |
Title
CUGB2 expression changes in pancreatic cancer cell lines (SU86, T3M4 and CAPAN1) treated with indomethacin
Viktorija Markovskaja, Nikolaj Markovskij, Dainius Plenta
Publisher (trusted)
Lietuvos biochemikų draugija
Date Issued
Date Issued |
---|
2010-06-15 |
Extent
p. 38-39, poster no. 25.
Is part of
XI international meeting of Lithuanian Biochemical Society “LBS 50”= Lietuvos Biochemikų Draugijos XI tarptautinė konferencija “LBD 50” : 15-17 June, 2010 / 2010 m. birželio 15-17 dd. Tolieja (Moletai region)/ Tolieja (Molėtų raj.) / Lietuvos biochemikų draugija / Lithuanian Biochemical Society ; [ Org. group/org. komitetas: Vida Mildažienė (pirm.) ir kt.]. Vilnius : Lietuvos biochemikų draugija ; Ciklonas, 2010. ISBN 9789955335719.
Version
Originalus / Original
Series/Report no.
Abstracts/Tezės.
Field of Science
Abstract
Cycloocxygenase-2 (COX-2) is a crucial enzyme in the conversion of arachidonic acid to prostaglandin E2 (PGE2) and is significantly upregulated in many types of adenocarcinomas. COX2 overexpression leads to increased PGE2 productions, resulting in increased cellular proliferation. CUGBP2 is RNA binding protein, involved in mRNA stabilization and translation silencing and responsible for cell apoptosis induction. It binds AU-rich sequences to regulate COX2 mRNA translation. PGE2 down regulates CUGBP2 expression. This data suggest that increased levels of COX2 and PGE2 may reduce apoptosis of cancer cells by inhibiting CUGBP2. [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9789955335719
Other Identifier(s)
(LSMU ALMA)990000731020107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Affiliation(s)