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Ischemia induced damages to cerebral cortex and cerebellum regions
Date Issued |
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2019-11-29 |
no. P15
Poster presentation.
ISBN 978-609-467-426-6 (online).
Background and aim:Ischemic brain injury is the leading cause of disability and mortality worldwide and the severity of damage is dependent on ischemia duration. Accumulated evidence indicate that mitochondria play a critical role in ischemic injury. The pharmaceutical agents often fail to deliver clinical value as females react differntly to treatment. Also, taking in consideration that cortex and cerebellum has a different composition of neuronal and glial cells, the aim of this work was to evaluate the activity of cerebral cortex and cerebellum mitochondria respiration, calcium retention capacity and the infarct zone size to evaluate 90 min and 120 min ischemia induced damages. Materials and methods: Experiments were performed on brain isolated from 3 months old Wistar rats and distributed into three groups: control, 90 min ischemia and 120 min ischemia. [...].