Use this url to cite publication: https://hdl.handle.net/20.500.12512/117370
Options
Relationship between oxidative stress and left ventricle markers in patients with chronic heart failure
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Mazgelytė, Agnė | ||
Title
Relationship between oxidative stress and left ventricle markers in patients with chronic heart failure
Aušra Mongirdienė, Agnė Liuizė, Dovilė Karčiauskaitė, Eglė Mazgelytė, Arūnas Liekis, Ilona Sadauskienė
Date Issued
Date Issued |
---|
2023-03-27 |
Extent
p. 1-2.
Is part of
5th Global Virtual Conference on Cardiology (Cardio Hub 2023) : March 27-28, 2023. [London] : Intellect Conferences Limited, 2023.
Version
Originalus / Original
Description
Oral Presentation. Poster
Iš laiško: Čia būtų medicina.Pagarbiai, Prof. Aušra Mongirdienė LSMU Medicinos akademijos Medicinos fakulteto Biochemijos katedra
Field of Science
Abstract
Aim: to verify if the serum oxidative stress markers differ in chronic heart failure (CHF) patients’ groups according to LV geometry and function. Patients were stratified into 1) two groups according to LV ejection fraction (LVEF): HFrEF (<40% (n=27)) and HFpEF (≥40% (n=33)); 2) four groups according to LV geometry: NG – normal left ventricle geometry (n=7), CR – concentric remodeling (n=14), cLVH – concentric LV hypertrophy (n=16), eLVF – eccentric LV hypertrophy (n=23). Protein carbonyl (PC), nitrotyrosine (NT-Tyr), dityrosine, malondialdehyde (MDA), oxidizes HDL and catalase activity, total plasma antioxidant capacity (TAC) markers in serum were measured. NT-Tyr, dityrosine, PC, MDA, oxHDL, TAC, catalase did not differ between the groups according to LVEF or LV geometry. NT-Tyr correlated with PC (rs = 0.482, p = 0.000098), and oxHDL (rs = 0.278, p = 0.0314). MDA correlated with total (rs = 0.337, p = 0.008), LDL (rs = 0.295, p = 0.022) and non-HDL (rs = 0.301, p = 0.019) cholesterol. NT-Tyr correlated with HDL (rs = -0.285, p = 0.027). LV parameters did not correlate with oxidative/ antioxidative stress markers. Significant negative correlations were found between the end-diastolic volume of the LV and the end-systolic volume of the LV and HDL-cholesterol (rs = –0.935, p < 0.0001; rs = –0.906, p < 0.0001, respectively). Conclusions. 1) No difference in serum concentrations of both oxidant (NT-Tyr, PC, MDA) and antioxidant (TAC and catalase) concentrations between the patients’ groups according to LV function and geometry was found. 2) Any correlation between oxidative / antioxidant and LV markers in CHF patients were found.
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)991698586307106
Coverage Spatial
Jungtinė Karalystė / United Kingdom of Great Britain and Northern Ireland (GB)
Language
Anglų / English (en)
Affiliation(s)