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Type of publication: conference paper
Type of publication (PDB): Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Medicina / Medicine (M001)
Author(s): Simonsen, Ulf;Hansson, Nicolaj;Rodriguez-Rodriguez, Rosalía;Andersen, Malene R;Stankevičius, Edgaras;Buus, Niels Henrik;Eskildsen-Helmond, Yvonne
Title: Anti-Atherogenic Effect of Oleanolic Acid Appears Unrelated to Endothelial Release of Nitric Oxide
Is part of: 10th International Symposium on Mechanisms of Vasodilatation - MOVD 2009 : June 1-3, 2009 Matsushima, Miyagi, Japan : program & Abstracts / Presidents: Hiroaki Shimokawa, Paul M. Vanhoutte ; Tohoku University et al. Miyagi : Miyagi Medical Association, 2009
Extent: p. 155, no. P1-3
Date: 2009
Series/Report no.: (Poster 1 Natural products 2009/06/01. Poster & Exhibition Chiyo2)
Keywords: Endothelium, vascular;analysis;Mesenteric artery, superior;Oleanolic acid;Nitric oxide
Abstract: The present study investigated the mechanisms by which oleanolic acid, a component of olive oil, increases release of nitric oxide (NO), and investigated the effect of oleanolic acid in an atherosclerotic animal model. Measurements of isometric tension, NO concentration, and endothelial cell calcium were performed in isolated rat mesenteric arteries. 8 weels ApoE-/- miee were feed a Western-type diet in combination with oleanolic acid (ApoE-/- -OA; 100 mg/kg/day), fluvastatin (ApoE-/--fluvastatin; 5 mg/kg/day), or vehicle (ApoE-/-- Vehicle). Wild type mice were used as negative controls. Oleanolic acicd, caused endothelium-dependent relaxation in large and small mesenteric arteries from rats. The release of NO was calcium-independent and due to phosphorylation of Akt and endothelial NO synthase at serine 1177. ln the animal study total plasma cholesterol levels were similar among all groups of ApoE-/-mice, while atherosclerotic plaque area was reduced in aorta from oleanolic acid-treated ApoE-/- and fluvastatin-treated ApoE-/- mice, compared to vehicle-treated ApoE-/-mice. Compared to vehicle and fluvastatin-treated ApoE-/- mice, aortic segments from wild type and oleanolic acid-treated ApoE-/-mice had a greater response to phenylephrine and less expression ofl inducible NO synthase. Actetylcholine relaxation was not improved in aortae from oleanolic acid or fluvastatin treated ApoE-/- mice. Oleanolic acid increases release of NO in isolated rat arteries and chronic administration of oleanolic acid has a pronounced anti-atherogenic effect in ApoE-/- mice, but the anti-atherogenic effect of oleanolic acid seems unrelated to endothelial release of NO
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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