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Electron microscopic study of intrinsic cardiac ganglia in the adult human / Neringa Pauziene, Dainius H. Pauza
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Institute of Anatomy I, Faculty of Medicine, Aachen University of Technology, RWTH Aachen, Germany |
Title
Electron microscopic study of intrinsic cardiac ganglia in the adult human / Neringa Pauziene, Dainius H. Pauza |
Publisher (trusted)
Elsevier |
Is Referenced by
BIOSIS Previews |
Elsevier BIOBASE/Current Awareness in Biological Sciences |
Date Issued
Date Issued |
---|
2003-04-01 |
Extent
p. 135-148.
Is part of
Annals of anatomy. , 2003, vol. 185, no. 2.
Version
Originalus / Original
Field of Science
Keywords
Abstract
The aim of the present study was to describe in detail the ultrastructure of intrinsic cardiac ganglionic cells in the healthy human as these cells appear to be directly involved in the development of tachycardia, atrioventricular block, ventricular fibrillation, and sudden cardiac death. Tissues examined in this study were obtained from hearts of 10 adult humans of either sex aged 22-80 years at autopsy performed no more than 8 h after death. The examined human intrinsic cardiac nerve cells were in most respects typical autonomic neurons surrounded by a sheath of satellite cells that was either uni- or multilayered. In addition to regular unmyelinated axons, prominent large axon terminals containing lamellated dense bodies, mitochondria and vesicles in the cytoplasm were observed in the ganglion neuropil. Synaptic profiles were more common in the ganglion neuropil than on neuronal somata. According to axon terminal contents, synaptic profiles were of three types. The most common Type 1 synaptic profiles contained a predominance of small clear, with a few larger dense-cored vesicles and mitochondria. Type 2 synaptic profiles, in addition to the same components as in Type 1, had glycogen-like particles. Type 3 vesicle-containing profiles clearly differed from both the previous ones as they were the largest in diameter and included plentifiul large clear pleomorphic or dense-cored vesicles together with small clear and larger dense-cored vesicles, mitochondria, dense and multivesicular bodies. Independently of age of the human, the most frequent neuronal abnormality was an abundant accumulation of inclusions inside of somata and dendrites that, in profile, appeared like circular membranous or fine granular bodies variable in electron density. In addition to inclusions, some neuronal somata and dendrites had strongly swollen mitochondria filled up with granular material in spite of their close association with normal looking ganglionic neurons.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
0940-9602
WOS
000182396200006
Other Identifier(s)
(LSMU ALMA)990000544490107106
Coverage Spatial
Vokietija / Germany (DE)
Language
Anglų / English (en)
Affiliation(s)