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Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: a focused review / Pedro de Sousa Gomes, Povilas Daugela, Lukas Poskevicius, Lorena Mariano, Maria Helena Fernandes
Type of publication
Straipsnis kitoje duomenų bazėje / Article in other database (S4)
Author(s)
Gomes, Pedro de Sousa | BoneLab, Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, U. Porto, Portugal | LAQV/REQUIMTE, Faculty of Dental Medicine, U. Porto, Porto, Portugal |
Mariano, Lorena | BoneLab, Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, U. Porto, Portugal | |
Fernandes, Maria Helena | Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Portugal | LAQV/REQUIMTE, Faculty of Dental Medicine, U. Porto, Porto, Portugal |
Title
Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: a focused review / Pedro de Sousa Gomes, Povilas Daugela, Lukas Poskevicius, Lorena Mariano, Maria Helena Fernandes
Extent
p. 1-18.
Is part of
Journal of Oral & Maxillofacial Research (JOMR). [Kaunas : Stilus optimus], 2019, vol. 10, no. 3.
Version
Originalus / Original
Description
This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included.
Field of Science
Abstract
Objectives: The present manuscript aims to critically detail the physiologic process of socket healing, in the absence or presence of grafting materials or platelet concentrates, addressing the associated molecular and cellular events that culminate in the restoration of the lost tissue architecture and functionality. Material and Methods: An electronic search in the National Library of Medicine database MEDLINE through its online site PubMed and Web of Science from inception until May 2019 was conducted to identify articles concerning physiologic process of socket healing, in the absence or presence of grafting materials or platelet concentrates. The search was restricted to English language articles without time restriction. Additionally, a hand search was carried out in oral surgery, periodontology and dental implants related journals. Results: In total, 122 literature sources were obtained and reviewed. The detailed biological events, at the molecular and cellular level, that occur in the alveolus after tooth extraction and socket healing process modulated by grafting materials or autologous platelet concentrates were presented as two entities. Conclusions: Tooth extraction initiates a convoluted set of orderly biological events in the alveolus, aiming wound closure and socket healing. The healing process comprises a wide range of events, regulated by the interplay of cytokines, chemokines and growth factors that determine cellular recruitment, proliferation and differentiation in the healing milieu, in a space- and time-dependent choreographic interplay. Additionally, the healing process may further be modulated by the implantation of grafting materials or autologous platelet concentrates within the tooth socket, aiming to enhance the regenerative outcome.
Type of document
type::text::journal::journal article::research article
ISSN (of the container)
2029-283X
Other Identifier(s)
(LSMU ALMA)990000995870107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
122