Veterinarijos Akademija (VA)

Data of anamnesis, clinical symptoms, and outcome of the disease.

The dataset contains pseudonymised participant-level data from a single-centre prospective observational cohort recruited at the Hospital of the Lithuanian University of Health Sciences Kauno klinikos within the research project CardioPathoGen. Participants were enrolled in three clinical groups: (1) patients with myocardial infarction (MI) undergoing urgent percutaneous coronary intervention, (2) patients with stable angina (SA) undergoing elective coronary angiography/intervention and (3) patients referred for assessment of coronary artery disease (CAD assessment group). For each participant the dataset includes demographic characteristics, cardiovascular risk factors, coronary angiography findings (stenosis by coronary segment, culprit vessel), routine laboratory tests (lipid profile, renal and liver tests, CRP, complete blood count, cardiac troponin I, BNP), echocardiographic parameters and light transmission platelet aggregation results in venous and coronary arterial blood after induction with ADP or adrenaline, with and without galectin-3. Additional files contain serum IgG results for seven viruses (ELISA), plasma bacterial 16S rRNA nanopore sequencing results for a PCR-selected subset including negative water controls, and a structured dental (periodontal) examination for the MI group. The data can be reused for studies of infectious and inflammatory exposures, platelet function and oral health in coronary artery disease, for meta-analyses and for method comparison.

Regenerative properties and clinical adaptability of platelet-rich fibrin have been discussed in previous human research, but information about its composition in animals is lacking. It has been reported that microRNAs play an essential role in wound healing and inflammatory process. In this study, we reported the presence of various microRNAs in the platelet-rich fibrin and other autologous blood products of canines, including confirmed stability properties. We believe this research might be a step forward in understanding the regenerative mechanisms and adapting new therapy methods that can be used in humans and animals based on One Health principles