DEPARTMENT OF DRUG CHEMISTRY

The University of Lithuania was founded in 1922. At that time, the Faculty of Medicine had four departments, including the Department of Pharmacy. There was only one joint Department of Pharmacy and Pharmacognosy founded and headed for a long time (until 1939) by Prof. Petras Raudonikis. In 1932, following the construction of the building of the Faculty of Medicine (A.Mickevičiaus g. 9), premises for the Department of Pharmacy and Pharmacognosy were completed on the third floor. When Kaunas University was reinstated in 1944, the Department was reorganised and replaced by two specialised departments: the Department of Pharmacy (later renamed the Department of Pharmaceutical Chemistry) and the Department of Botany and Pharmacognosy. The Department of Pharmaceutical Chemistry was headed by Prof. B. Šiaulis for a long time, from 1939 until his death in 1957.

In 1957-1972, the Department was headed by Assoc. Prof. V. Brasiūnas, in 1972-1983 – by Assoc. Prof. E. Tarasevičius. In 1978-2008, the Department of Pharmaceutical Chemistry and Pharmacognosy was reinstated and headed by Assoc. P. Vainauskas in 1983-1987, Assoc. Prof. F. Malinauskas in 1987-1993, and Prof. V. Janulis in 1993-2008. In 2008, the Department of Pharmaceutical Chemistry and Pharmacognosy was again reorganised into two departments: the Department of Pharmacognosy and Department of Drug Chemistry. In 2008-2017, the Department of Drug Chemistry was headed by Prof. H. Rodovičius. Since 2018, the Department of Drug Chemistry has been headed by Prof. R. Morkūnienė.

OUR ACTIVITIES

Mandatory subjects

Mandatory courses

Integrated study programme “Pharmacy”:

  • “Pharmacogenomics and Drug Metabolism” for the 3rd year students;
  • Module “Pharmaceutical Chemistry” for the 3rd year students;
  • Module “Drug Chemistry” (Neuropharmacy, Cardiopharmacy and Endocrine Drugs, Oncopharmacy and Inflammation) for the 4th year students;
  • Part “Quality of drugs” of the module “Development of Pharmaceutical Products” for the 5th year students;
  • Part “Organisation and evaluation of practice in drug analysis in pharmacy” of the module “Professional Practice in Pharmacy” for the 5th year students;
  • Final Master’s thesis for the 4th and 5th year students;
  • Elective courses: “Development of drug substances”, “Interactions between antibiotics, bacteria and the macro-organism”.

First-cycle study programme “Medical and Veterinary Biochemistry” (Faculty of Medicine):

  • “Pharmaceutical Biochemistry” for the 3rd year students.

Second-cycle joint KTU-LSMU study programme “Medicinal Chemistry”:

  • Part  “Pharmaceutical Chemistry” of the module “Pharmacognosy and Pharmaceutical Chemistry” for the 1st year students.
  • Research Project I
  • Research Project II
  • Master’s Thesis

Main research topic: “Synthesis, analysis and study of the effects of biologically active compounds on living organisms.”, 2023–2027

Our research areas:

    1. In vitro development of cell models for the studies of the efficacy of new drugs
    2. Identification and study of plant-derived multifactorial antioxidants
    3. Pharmacogenetic studies of cardiovascular diseases

Cooperation with the Institute of Cardiology in the project “Coronary Heart Disease Links with Bacteria and Viruses” (Research Group Projects, XIII Call). No. S-MIP-24-125, LSMU project. Project value: EUR 196,414.31. Project leader: Prof. Vacis Tatarūnas. Implementation period: 2024–2027.

“Application of Plant Cultures for the Development of Health Products” (Medicine and Health Sciences, Pharmacy), doctoral project conducted together with UAB “Exolitus”. Funded by the Research Council of Lithuania. P-PAD-24-59. PhD student Sofiya Haluts. LSMU supervisor Prof. Ramunė Morkūnienė. UAB “Exolitus” supervisor Dr Aistė Jekabsone. Implementation period: 2024–2029.

Project “Study of phytochemical composition, antioxidant and anti-inflammatory activity of plant nanoparticles” under the EU Funds Investment Action Programme Measure No. 09.3.3-LMT-K-712 “Development of scientific competence of scientists, other researchers, students through practical scientific activities”. Project leader: Dr. Justina Dambrauskienė. Implementation period: 2024.

COST activity European Network for Skin Engineering and Modeling, (NETSKINMODELS). No. CA21108. Participants: Prof. R. Morkūnienė, G. Kulkovienė. Implementation period: 2022–2026.

Cooperation with the Institute of Cardiology in the project JPIAMR-ACTION Joint Transnational Call for Proposals 2023. “Development of innovative strategies, tools, technologies, and methods for diagnostics and surveillance of antimicrobial resistance (DISTOMOS)”. LSMU and KTU together with researchers from Poland and Sweden. Project leader: Prof. Vacis Tatarūnas. Implementation period: 2023–2024.

Project “Study of the effect of plant extracts on skin cells with a psoriasis phenotype” under the EU Funds Investment Action Programme Measure No. 09.3.3-LMT-K-712 “Development of scientific competence of scientists, other researchers, students through practical scientific activities”. Project leader Prof. Ramunė Morkūnienė, participant: doctoral student Gabrielė Kulkovienė. Implementation period: 2022.

Cooperation with the framework of project “Exosome Application for Targeted Drug Delivery” (EXOTARGET) funded under measure No. 01.2.2-LMT-K-718-01-0036 “Targeted Research in Smart Specialisation Areas”. Implementation period: 2017–2022. Project manager: Dr. Aistė Jekabsone. Project value: EUR 499,872.20. Project implementers: Prof. R. Morkūnienė, PhD student G. Vydmantaitė.

Cooperation with the Institute of Pharmaceutical Technologies under Measure No. J05-LVPA-K-01-0248 “Intellect. Joint Science-Business Projects“: “Promotion of UAB Akvavita investments in R&D activities by developing innovative products in the beverage industry”. Project manager Prof. Dr. V. Jakštas. Project value: EUR 315,887.22. Project implementer: Prof. R. Morkūnienė.

Cooperation under the bilateral research project of Lithuania and Japan by the Neuroscience Institute: “Study of the molecular determinants of Alzheimer’s disease: the relationship between extracellular tau, beta amyloid, and neuroinflammation” (INFLAMATAU), the Research Council of Lithuania. Source of funding: the Research Council of Lithuania. Implementation period: 2018–2020. Project manager: R. Morkūnienė.

Joint LSMU-KTU project “Generation of o-Quinone Methides and Investigation Their Conjugates and Metabolites in Saccharomyces Cerevisiae Lag and Log Phases” (CHINONMETIDAS). Project manager: R. Morkūnienė. Project implementer: L. Šlepikas. Source of funding: the LSMU Research Fund, 2019.

Cooperation under project No. 01.2.2-LMT- K-718-01-0038 “Point-of-Care method for ticagrelor pharmacogenomics” (OPTOGEN) jointly funded from the structural funds of the European Union, coordinated by the Institute of Cardiology. Project implementer: V. Tatarūnas. Source of funding: the Research Council of Lithuania, SMART project funds.

Cooperation with UAB SynHet (headed by L. Šlepikas) under project No. 01.2.1-LVPA-K-856-01-0188 “Development of high potency compounds against S. aureus based on the in silico chemogenomics, in vitro and in vivo studies”. Implementation period: 2020-2022. Project value: EUR 534,061.00

Cooperation with UAB SynHet (headed by L. Šlepikas) under project No. 01.2.2-MITA-K-702-06-0018 “Development of the adaptive robotic separation system”. Implementation period: 2020-2021. Project value: EUR 99,000.

Cooperation under project No. 01.2.2-LMT-K-718-05-0052 “Technology for the management of COVID-19-induced mitochondrial dysfunction of cardiovascular system” (cTECH) coordinated by the Institute of Cardiology. Project manager: Dr. Aistė Jekabsone. Project value: EUR 299,965.66. Implementation period: 2021-2023. Project manager: PhD student G. Vydmantaitė.

Cooperation with UAB SynHet (headed by L. Šlepikas) under project BIOTECH-02-006 “Development of in silico chemogenomics-based biologically active compounds against K. pneumoniae, A. baumannii, P. aeruginosa, and Enterobacter spp.”. Project manager: Liudas Ivanauskas. Project value: EUR 194,793.00.

Neuroscience Institute (LSMU)

Institute of Cardiology (LSMU)

Department of Biochemistry (Faculty of Medicine, LSMU Medical Academy)

Department of Neurology (Faculty of Medicine, LSMU Medical Academy)

Department of Plastic and Reconstructive Surgery (Faculty of Medicine, LSMU Medical Academy)

Kaunas University of Technology

Vilnius University Life Sciences Centre

State Medicines Control Agency under the Ministry of Health of the Republic of Lithuania

Kharkiv National University of Pharmacy, Department of Pharmaceutical Chemistry (Ukraine)

Medical University of Bialystok, Department of Pharmaceutical and Bio-Pharmaceutical Analysis (Poland)

University of Copenhagen, Department of Neuroscience (Denmark)

University of Tartu, Institute of Pharmacy under the Faculty of Medicine (Estonia)

Houston Methodist Research Institute, Department of Nanomedicine (the U.S.)

Association of the European Self-Medication Industry

Business partners: EXOLITUS, UAB; Aconitum, UAB

University of Tartu, Institute of Pharmacy under the Faculty of Medicine (Estonia)

Department of Drug Chemistry
Sukilėlių pr. 13, Kaunas, Lithuania
Prof. Dr Ramunė Morkūnienė
Dean of the Faculty of Pharmacy, Medical Academy
All contacts